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Thiostrepton

Cat No. 3267

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Biological Activity

Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Technical Data

M.Wt:

1664.89

Formula:

C₇₂H₈₅N₁₉O₁₈S₅

Solubility:

Soluble to 10 mM in DMSO

Purity:

>90 %

Storage:

Store at -20°C

CAS No:

[1393-48-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Rodnina et al (1999) Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc.Natl.Acad.Sci.USA 96 9586. Ruben et al (2007) Thiostrepton inhibition of tRNA delivery to the ribosome. RNA 13 2091. Kwok et al (2008) Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol.Cancer Ther. 7 2022.

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Keywords: Thiostrepton, Downregulates, FOXM1, Antibiotic, inhibits, inhibitors, Hh, Signaling, Signalling, Hedgehog, Transcription, Factors, protein, synthesis