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SB 505124

Cat. No. 3263

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Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine

Biological Activity

Selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC₅₀ values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members.

Technical Data

M.Wt:

335.4

Formula:

C₂₀H₂₁N₃O₂

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

694433-59-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Byfield et al (2004) SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 65 744. PMID: 14978253.

Hu et al (2005) Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells. Am.J.Physiol.Renal Physiol. 289 F816. PMID: 16159901.

Noma et al (2008) The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 134 1981. PMID: 18439605.

If you know of a relevant citation for this product please let us know.

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Keywords: SB 505124, supplier, SB505124, tgfβ, tgfbeta, tgfb, tgfbrI, tgfbetarI, tgfβrI, receptors, transforming, growth, factors, alk5, alk4, alk7, inhibitors

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