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Epirubicin hydrochloride

Cat No. 3260

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Alternative Name: 4'-Epidoxorubicin

Chemical Name: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-a-L-arabino-hexopy ranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2 -hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride

Biological Activity

Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC₅₀ = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.

Technical Data

M.Wt:

579.98

Formula:

C₂₇H₂₉NO₁₁.HCl

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

>97 %

Storage:

Desiccate at +4°C

CAS No:

[56390-09-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Cersosimo et al (1986) Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J.Clin.Oncol. 4 425. Spadari et al (1986) DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Res. 6 935. Schott and Robert (1989) Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem.Pharmacol. 38 4069.

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