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PJ 34 hydrochloride

Cat No. 3255

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Chemical Name: N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride

Biological Activity

Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC₅₀ = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide. Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo.

Technical Data

M.Wt:

331.8

Formula:

C₁₇H₁₇N₃O₂.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[344458-15-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Abdelkarim et al (2001) Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int.J.Mol.Med. 7 255. Haddad et al (2006) Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br.J.Pharmacol. 149 23. Gambi et al (2008) Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol. 75 2356.

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Keywords: PJ 34 hydrochloride, Potent, PARP, inhibitors, PolyADP-ribose, Polymerases, PJ34, hydrochloride

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Written by E. Besancon et al

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

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