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KC 12291 hydrochloride

Cat No. 3251

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Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol -3-yl)oxy]propyl]benzeneethanamine hydrochloride

Biological Activity

Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (I_NaL) and prevents diastolic contracture in isolated atria in vitro (IC₅₀ values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

Technical Data

M.Wt:

449.99

Formula:

C₂₂H₂₇N₃O₃S.HCl

Solubility:

Soluble to 25 mM in water and to 50 mM in DMSO

Purity:

>97 %

Storage:

Desiccate at +4°C

CAS No:

[181936-98-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547. Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346. John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17. Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243.

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Keywords: KC 12291 hydrochloride, Orally, active, atypical, Na+, blockers, cardioprotective, Sodium, NaV, Channels, voltage-gated, voltage-dependent, KC12291, hydrochloride

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