Cat. No. 3242
Chemical Name: 1,4-Dihydro-4-[3-[[[[3-[4-(3-methox
Biological ActivityPotent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Poindexter et al (2002) Dihydropyridine neuropeptide Y Y1 receptor antagonists. Bioorg.Med.Chem.Letts. 12 379.
Poindexter et al (2004) Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements Bioorg.Med.Chem. 12 507. PMID: 14723969.
Antal-Zimanyi et al (2008) Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist Eur.J.Pharmacol. 590 224. PMID: 18573246.
If you know of a relevant citation for this product please let us know.
Keywords: BMS 193885, supplier, Potent, competitive, NPY, Y1, antagonists, Peptide, Receptors, Neuropeptide, Y, BMS193885, neuropeptides
Find multiple products by catalog number
New Products in this Area
NPY Y5 receptor antagonistTC-FPR 43
Potent FPR2 agonistTC-G 1003
High affinity somatostatin sst2 receptor agonistKisspeptin 10 (dog)
Endogenous ligand for canine kisspeptin receptorMK 0677
High affinity ghrelin receptor agonistUrantide
Selective and competitive urotensin II antagonist
April 18 - 22, 2015