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BMS 193885

Cat No. 3242

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Chemical Name: 1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidin yl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5 -pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate

Biological Activity

Potent, competitive neuropeptide (NPY) Y₁ antagonist (K_i = 3.3 nM, IC₅₀ = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ₁, α₁, Y₂, Y₄ and Y₅ receptors respectively. Reduces food intake and body weight via central Y₁ inhibition and is brain penetrant.

Technical Data

M.Wt:

680.79

Formula:

C₃₃H₄₂N₄O₆.C₃H₆O₃

Solubility:

Soluble to 20 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

[186185-03-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch

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References

Poindexter et al (2002) Dihydropyridine neuropeptide Y Y1 receptor antagonists. Bioorg.Med.Chem.Letts. 12 379. Poindexter et al (2004) Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements. Bioorg.Med.Chem. 12 507. Antal-Zimanyi et al (2008) Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist. Eur.J.Pharmacol. 590 224.

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Keywords: BMS 193885, Potent, competitive, NPY, Y1, antagonists, Peptide, Receptors, Neuropeptide, Y, BMS193885

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