SCH 221510Cat No.
3240
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Price and Availability |
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Chemical Name: 3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicy clo[3.2.1]octan-3-ol |
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Biological Activity
Potent and selective nociceptin opioid receptor (NOP) agonist (EC50 values are 12, 693, 683 and 8071 nM, and Ki values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively). Exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo. Orally active.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Varty et al (2008) The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). J.Pharmacol.Exp.Ther. 326 672. Lambert (2008) The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential. Nat.Rev.Drug Discov. 7 694. Yang et al (2009) Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety. Bioorg.Med.Chem.Lett. 19 2482.If you know of a useful citation for this product please let us know.
Keywords: SCH 221510, SCH221510, NOP, nociceptin, opioid, receptors, agonists, ORL1
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