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BIM 23042

Cat No. 3237

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Biological Activity

Selective neuromedin B receptor (NMB-R, BB₁) antagonist (K_i values are 216 and 18,264 nM for BB₁ and BB₂ receptors respectively). Displays no activity at a range of other receptors.

Technical Data

M.Wt:

1192.46

Formula:

C₆₃H₇₃N₁₁O₉S₂

Sequence:

XCYWKVCX

(Modifications: X-1 = D-Nal, Trp-4 = D-Trp, X-8 = Nal-amide)

Storage:

Desiccate at -20°C

CAS No:

[111857-96-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Orbuch et al (1993) Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol.Pharmacol. 44 841. Ryan et al (1996) Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur.J.Pharmacol. 306 307. Milusheva et al (1998) Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract. Peptides 19 549.

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Keywords: BIM 23042, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23042

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