Cat. No. 3231
Biological ActivityN-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.
(Modifications: Gln-1 = N-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Walther et al (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol.Cell 5 831. PMID: 10882119.
Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762.
Rabiert et al (2007) The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview. Biochimie 89 1089. PMID: 17428601.
If you know of a relevant citation for this product please let us know.
Keywords: Ac9-25, supplier, Annexin, I, N-terminal, peptide, Acts, FPR1, ligands, FPRL, Formyl, Peptide, Receptors
Find multiple products by catalog number
New Products in this Area
Potent neuropeptide S receptor (NPSR) antagonistTC OT 39
Nonpeptide oxytocin and V2 receptor partial agonist; also a V1a receptor antagonistTolvaptan
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally activeML 00253764 hydrochloride
Melanocortin MC4 receptor antagonist; brain penetrantGSK 1562590 hydrochloride
High affinity, selective urotensin II (UT) receptor antagonistMA 2029
Potent and selective, competitive motilin receptor antagonist; orally activeANQ 11125
Selective motilin receptor antagonist
October 5 - 8, 2014