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Ac9-25

Cat No. 3231

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Biological Activity

N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.

Technical Data

M.Wt:

2183.35

Formula:

C₉₉H₁₄₃N₂₃O₃₃

Sequence:

QAWFIENEEQEYVQTVK

(Modifications: Gln-1 = N-terminal amide)

Storage:

Desiccate at -20°C

CAS No:

[284040-76-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Walther et al (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol.Cell 5 831. Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762. Rabiert et al (2007) The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview. Biochimie 89 1089.

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Keywords: Ac9-25, Annexin, I, N-terminal, peptide, Acts, FPR1, ligands, FPRL, Formyl, Peptide, Receptors

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