Sar-[D-Phe8]-des-Arg9-Bradykinin

Cat. No. 3230

Sar-[D-Phe8]-des-Arg9-Bradykinin Sar-Arg-Pro-Pro-Gly-Phe-Ser-Pro-D-Phe

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Biological Activity

Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Technical Data

M.Wt:
975.11
Formula:
C47H66N12O11
Sequence:
XRPPGFSPF

(Modifications: X = Sar, Phe-9 = D-Phe)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
126959-88-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997. PMID: 1662280.

Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192. PMID: 8392550.

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Sar-[D-Phe8]-des-Arg9-Bradykinin, supplier, Potent, selective, B1, agonists, Receptors, Bradykinin

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