Cat. No. 3230
Biological ActivityPotent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
(Modifications: X = Sar, Phe-9 = D-Phe)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997. PMID: 1662280.
Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192. PMID: 8392550.
Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727.
If you know of a relevant citation for this product please let us know.
Keywords: Sar-[D-Phe8]-des-Arg9-Bradykinin, supplier, Potent, selective, B1, agonists, Receptors, Bradykinin
Find multiple products by catalog number
New Products in this Area
Endogenous ligand for canine kisspeptin receptorMK 0677
High affinity ghrelin receptor agonistUrantide
Selective and competitive urotensin II antagonistML 154
Potent neuropeptide S receptor (NPSR) antagonistTC OT 39
Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonistTolvaptan
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.