Home » Pharmacology » 7-TM Receptors » Peptide Receptors » Bradykinin Receptors » Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Cat. No. 3230

Sar-[D-Phe8]-des-Arg9-Bradykinin Sar-Arg-Pro-Pro-Gly-Phe-Ser-Pro-D-Phe

Price and Availability

For Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Potent and selective bradykinin B₁ receptor agonist (EC₅₀ = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

Technical Data

M.Wt:

975.11

Formula:

C₄₇H₆₆N₁₂O₁₁

Sequence:

XRPPGFSPF

(Modifications: X = Sar, Phe-9 = D-Phe)

Solubility:

Soluble to 2 mg/ml in 30% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

126959-88-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg⁹-Bradykinin and metabolically protected agonists of B¹ receptors for kinins. J.Pharmacol.Exp.Ther. 259 997. PMID: 1662280.

Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B₁ receptors for kinins. J.Pharmacol.Exp.Ther. 266 192. PMID: 8392550.

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Bradykinin Receptors

Peptide Receptors

Keywords: Sar-[D-Phe8]-des-Arg9-Bradykinin, supplier, Potent, selective, B1, agonists, Receptors, Bradykinin

Quick Order

Find multiple products by catalog number

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy