Cat. No. 3224
Chemical Name: (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Penta
Biological ActivityPure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Van de Velde et al (1996) RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59 449.
Muller et al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263. PMID: 9443403.
Ameller et al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in estradiol-dependent cancers. J.Steroid Molec.Biol. 92 1.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: RU 58668, supplier, RU58668, pure, antiestrogen, antioestrogen, estrogen, receptors, ER
Find multiple products by catalog number
New Products in this Area
High affinity aryl hydrocarbon receptor (AhR) agonistML 179
Selective liver receptor homolog 1 (LRH1) inverse agonistAC 186
Potent and selective ERβ agonist; neuroprotectiveIsotretinoin
Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation
November 5-9, 2015