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TCS JNK 6oCat. No. 3222 |
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Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide |
Biological Activity
ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.Certificate of Analysis / Safety Data Sheet
References
Szczepankiewicz et al (2006) Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 49 3563. PMID: 16759099.
Kauskot et al (2007) Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J.Biol.Chem. 282 31990. PMID: 17785464.
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Keywords: TCS JNK 6o, supplier, TCSJNK6o, c-Jun, N-terminal, kinase, JNK, inhibitors, JNK1, JNK2, JNK3
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