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TCS JNK 6o

Cat. No. 3222

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Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide

Biological Activity

ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC₅₀ values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC₅₀ = 920 nM) and prevents collagen-induced platelet aggregation in vitro.

Technical Data

M.Wt:

356.38

Formula:

C₁₈H₂₀N₄O₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

894804-07-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Szczepankiewicz et al (2006) Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 49 3563. PMID: 16759099.

Kauskot et al (2007) Involvement of the mirogen-activated protein kinase c-Jun NH₂-terminal kinase 1 in thrombus formation. J.Biol.Chem. 282 31990. PMID: 17785464.

If you know of a relevant citation for this product please let us know.

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Keywords: TCS JNK 6o, supplier, TCSJNK6o, c-Jun, N-terminal, kinase, JNK, inhibitors, JNK1, JNK2, JNK3

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