Cat. No. 3214
Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1
Biological ActivityAntitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kravchenko et al (2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA 105 6302.
If you know of a relevant citation for this product please let us know.
Keywords: RETRA hydrochloride, supplier, Antitumor, agent, suppresses, mutant, p53-bearing, Transcription, Factors, p73
Find multiple products by catalog number
New Products in this Area
Stabilizes G-quadruplexes; inducing DNA damage and cell cycle arrestSCH 529074
Restores mutant p53 activity
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.