R&D Systems Inc. Tocris Bioscience Boston Biochem

RETRA hydrochloride

Cat. No. 3214

RETRA hydrochloride C11N11NO3S2.HCl [1173023-52-3]

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Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride

Biological Activity

Antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.

Technical Data

M.Wt:
305.8
Formula:
C11N11NO3S2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1173023-52-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kravchenko et al (2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA 105 6302.

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View Related Products by Target

Keywords: RETRA hydrochloride, supplier, Antitumor, agent, suppresses, mutant, p53-bearing, Transcription, Factors, p73

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