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RETRA hydrochlorideCat. No. 3214 |
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Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride |
Biological Activity
Antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.Certificate of Analysis / Safety Data Sheet
References
Kravchenko et al (2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA 105 6302.
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Keywords: RETRA hydrochloride, supplier, Antitumor, agent, suppresses, mutant, p53-bearing, Transcription, Factors, p73
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