SB 525334Cat No. 3211 |
Price and Availability |
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Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-im idazol-4-yl]quinoxaline |
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Biological Activity
Selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localisation and TGF-β1-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.Licensing Information
Sold with the permission of GlaxoSmithKlineTechnical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Grygielko et al (2005) Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-b type I receptor kinase in puromycin-induced nephritis. J.Pharmacol.Exp.Ther. 313 943. Higashiyama et al (2007) Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. Exp.Mol.Pathol. 83 39. Laping et al (2007) Tumor-specific efficacy of transforming growth factor-bRI inhibition in eker rats. Clin.Cancer Res. 13 3087.If you know of a useful citation for this product please let us know.
Keywords: SB 525334, Selective, inhibitors, TGF-βRI, TGF-β, TGF-betaRI, TGFbRI, TGFbR1, tgf-b1Transforming, Growth, Factor, Beta, Receptors, TGF-β, TGF-beta, Receptor, Serine/Threonine, Kinases, RSTKs, SB525334, GlaxoSmithKline
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