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BIO

Cat. No. 3194

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Alternative Name: 6BIO

Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-oxime

Biological Activity

Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC₅₀ values are 5, 83, 300, 320 and > 10 000 nM at GSK-3, CDK5/p25, CDK2/cyclin A, CDK1/cyclin B and other common kinases respectively). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro; also promotes proliferation and dedifferentiation in cardiomyocytes.

Technical Data

M.Wt:

356.17

Formula:

C₁₆H₁₀BrN₃O₆

Solubility:

Soluble to 10 mM in DMSO and to 10 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

667463-62-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Meijer et al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633.

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibtors of glycogen synthase kinase-3 and cyclin dependent kinases. J.Med.Chem. 47 935. PMID: 14761195.

Tseng et al (2006) The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem.Biol. 13 957. PMID: 16984885.

If you know of a relevant citation for this product please let us know.

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Keywords: BIO, supplier, Potent, selective, GSK-3, inhibitors, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, stem, cells

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