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[cPP^1-7,NPY^19-23,Ala³¹,Aib³²,Gln³⁴] - hPancreatic Polypeptide

Cat. No. 1365

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2

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Biological Activity

Potent, selective peptide agonist for the neuropeptide Y Y₅ receptor (IC₅₀ values for inhibition of NPY binding to human Y₅, Y₁, Y₂ and Y₄ receptors are 0.24, 530, > 500, and 51 nM respectively, K_i at Y₅ = 0.1 - 0.15 nM). Stimulates food intake in vivo.

Technical Data

M.Wt:

4207.67

Formula:

C₁₈₃H₂₈₀N₅₆O₅₅S₂

Sequence:

GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY

(Modifications: X = Aib, Tyr-36 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 10% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

313988-89-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Cabrele et al (2000) The first selective agonist for the neuropeptide YY₅ receptor increases food intake in rats. J.Biol.Chem. 275 36043. PMID: 10944518.

Dumont et al (2005) BODIPY�-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. Br.J.Pharmacol. 146 1069. PMID: 16231000.

If you know of a relevant citation for this product please let us know.

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Keywords: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide, supplier, Potent, selective, neuropeptide, Y, Y5, agonists, Neuropeptide, Receptors, neuropeptides

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