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SB 399885 hydrochloride

Cat. No. 3189

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Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride

Biological Activity

Potent, brain penetrant, orally active 5-HT₆ antagonist. Displays > 200-fold selectivity for 5-HT₆ over other 5-HT receptors (pK_i values are 9.11, 8.81 and 9.02� for human recombinant, native rat and native human 5-HT₆ receptors respectively).

Technical Data

M.Wt:

482.81

Formula:

C₁₈H₂₁Cl₂N₃O₄S.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

402713-80-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Hirst et al (2006) SB-399885 is a potent, selective 5-HT₆ receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 553 109.

Wesolowska and Nikiforuk (2007) Effects of the brain-penetrant and selective 5-HT₆ receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52 1274. PMID: 17320917.

Foley et al (2008) The selective 5-HT₆ receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166. PMID: 18455201.

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