SB 399885 hydrochloride

Cat. No. 3189

SB 399885 hydrochloride C18H21Cl2N3O4S.HCl [402713-81-9]

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Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride

Biological Activity

Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02  for human recombinant, native rat and native human 5-HT6 receptors respectively).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hirst et al (2006) SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 553 109.

Wesolowska and Nikiforuk (2007) Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52 1274. PMID: 17320917.

Foley et al (2008) The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166. PMID: 18455201.

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Keywords: SB 399885 hydrochloride, supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB399885, hydrochloride, 5-HT6 Receptor Antagonists

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