Cat. No. 3185
Chemical Name: 2-Chloro-5-[2-Phenyl-5-(4-pyridinyl
Biological ActivityPotent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Shelton et al (2003) Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 17 1765. PMID: 12970777.
White (2003) Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals. Leukemia 17 1759. PMID: 12970775.
Takle et al (2006) Identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Letts. 16 378.
Röring et al (2012) Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling. EMBO J. 31 2629. PMID: 22510884.
If you know of a relevant citation for this product please let us know.
Keywords: L-779,450, supplier, Potent, raf, kinases, inhibitors, a-raf, raf-1, L779450
Find multiple products by catalog number
New Products in this Area
Potent DYRK1B inhibitorETP 45658
Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTORPFK 15
Selective PFKFB3 inhibitorPD 0332991 isethionate
Potent, selective Cdk4/6 inhibitor; brain penetrantXL 413 hydrochloride
Potent and selective Cdc7 inhibitorC16
PKR inhibitorRp-8-pCPT-cGMPS sodium
PKG inhibitorTC-S 7004
Potent and selective DYRK1A/B inhibitorTAK 960 hydrochloride
Potent and selective PLK1 inhibitorA12B4C3
Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitorBMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatoryWH-4-023
Potent and selective Lck and Src inhibitor; also inhibits SIKTC-S 7006
Potent and selective Tpl2 (Cot; MAP3K8) inhibitorOXA 06 dihydrochloride
Potent ROCK inhibitorPCI 29732
Potent BTK inhibitorMps1-IN-1 dihydrochloride
Selective monopolar spindle 1 (Mps1) kinase inhibitorCKI 7 dihydrochloride
CK1 inhibitorT 5601640
Selective LIMK2 inhibitor; antitumor3PO
PFKFB3 inhibitor; antiangiogenic
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.