Cat. No. 3185
Chemical Name: 2-Chloro-5-[2-Phenyl-5-(4-pyridinyl
Biological ActivityPotent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Shelton et al (2003) Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 17 1765. PMID: 12970777.
White (2003) Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals. Leukemia 17 1759. PMID: 12970775.
Takle et al (2006) Identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Letts. 16 378.
Röring et al (2012) Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling. EMBO J. 31 2629. PMID: 22510884.
If you know of a relevant citation for this product please let us know.
Keywords: L-779,450, supplier, Potent, raf, kinases, inhibitors, a-raf, raf-1, L779450
Find multiple products by catalog number
New Products in this Area
Selective monopolar spindle 1 (Mps1) kinase inhibitorCKI 7 dihydrochloride
CK1 inhibitorT 5601640
Selective LIMK2 inhibitor; antitumor3PO
PFKFB3 inhibitor; antiangiogenicCHR 6494 trifluoroacetate
Potent and selective haspin kinase inhibitorUNC 3230
Potent and selective PIP5K1C inhibitor; antinociceptivetrans-ISRIB
Integrated stress response (ISR) inhibitortrans-ISRIB
Integrated stress response (ISR) inhibitorBMS 509744
Potent and selective ITK inhibitorWZ 4003
Potent and selective NUAK1/2 inhibitorTC-S 7010
Potent and selective Aurora kinase A inhibitorBryostatin 2
Protein kinase C activatorZLN 024 hydrochloride
Allosteric AMPK activatorTemsirolimus
mTOR inhibitor; antitumorKN 93 phosphate
CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).ETP 45835 dihydrochloride
Mnk1 and Mnk2 inhibitorBryostatin 3
Potent protein kinase C activatorGKA 50
March 18 - 21, 2015
Göttingen University, Germany