R&D Systems Inc. Tocris Bioscience Boston Biochem

Harmane

Cat. No. 1132

Harmane C12H10N2 [486-84-0]

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Alternative Name: Harman

Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole

Biological Activity

Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).

Technical Data

M.Wt:
182.22
Formula:
C12H10N2
Solubility:
Soluble to 10 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at RT
CAS No:
486-84-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 4646.

Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209. PMID: 7130973.

Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35. PMID: 10415895.

Hudson et al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 126 2P.

Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057. PMID: 10725251.

If you know of a relevant citation for this product please let us know.

Keywords: Harmane, supplier, MAO-A, MAO-B, inhibitor, putative, endogenous, imidazolines, ligand, MAO, monoamine, oxygenases, oxidases, I1, I2

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