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HarmaneCat. No. 1132 |
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Alternative Name: Harman Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole |
Biological Activity
Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).Certificate of Analysis / Safety Data Sheet
References
Merck Index 12 4646.
Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209. PMID: 7130973.
Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35. PMID: 10415895.
Hudson et al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 126 2P.
Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057. PMID: 10725251.
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Keywords: Harmane, supplier, MAO-A, MAO-B, inhibitor, putative, endogenous, imidazolines, ligand, MAO, monoamine, oxygenases, oxidases, I1, I2
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