Cat. No. 1132

Harmane C12H10N2 [486-84-0]

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Alternative Name: Harman

Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole

Biological Activity

Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).

Technical Data

Soluble to 10 mM in 1eq. HCl
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Merck Index 12 4646.

Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209. PMID: 7130973.

Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35. PMID: 10415895.

Hudson et al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 126 2P.

Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057. PMID: 10725251.

If you know of a relevant citation for this product please let us know.

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Keywords: Harmane, supplier, MAO-A, MAO-B, inhibitor, putative, endogenous, imidazolines, ligand, MAO, monoamine, oxygenases, oxidases, I1, I2, General Imidazoline Ligands

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