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K 114

Cat. No. 3144

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Chemical Name: 4,4'-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol

Biological Activity

Potent amyloid fibril-specific fluorescent dye (EC₅₀ = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of Aβ, α-synuclein and tau in situ. (Optimum wavelength = 550 nM).

Technical Data

M.Wt:

393.27

Formula:

C₂₂H₁₇BrO₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

872201-12-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Crystal et al (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J.Neurochem. 86 1359. PMID: 12950445.

LeVine (2005) Mechanism of Aβ(1-40) fibril-induced fluorescence of (trans-trans)-1-bromo-2,5-bis(4-hydroxystyryl)benene (K114). Biochemistry 44 15937. PMID: 16313197.

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Keywords: K 114, supplier, Amyloid, fibril-specific, fluorescent, dye, Fluorescent, Probes, Beta, Precursor, Protein, APP, Secretase, β-Amyloid, beta-Amyloid, b-amyloid, Peptides, K114

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