R&D Systems Inc. Tocris Bioscience Boston Biochem

KM 11060

Cat. No. 3143

KM 11060 C19H17Cl2N3O2S [774549-97-2]

Price and Availability

For KM 11060 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

Biological Activity

Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.

Technical Data

M.Wt:
422.33
Formula:
C19H17Cl2N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
774549-97-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Robert et al (2008) Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 73 478. PMID: 17975008.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: KM 11060, supplier, Corrects, F508del-CFTR, trafficking, Cl-, Channels, VSAC, Chloride, KM11060, pharmacochaperones

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

Sign-up for New Product E-alerts

Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

PPQ 102

Potent, voltage-independent CFTR chloride channel inhibitor

Monensin sodium salt

Sodium ionophore; antibacterial agent

Sign-up for new product e-alerts
divider line

Bio-Techne Events

2014 ASCB/IFCB meeting

ASCB/IFCB 2014

December 6 - 10, 2014

Philadelphia, USA

Booth Number: 515