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KM 11060

Cat. No. 3143

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Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

Biological Activity

Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.

Technical Data

M.Wt:

422.33

Formula:

C₁₉H₁₇Cl₂N₃O₂S

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

>98 %

Storage:

Store at RT

CAS No:

774549-97-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Robert et al (2008) Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 73 478. PMID: 17975008.

If you know of a relevant citation for this product please let us know.

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Keywords: KM 11060, supplier, Corrects, F508del-CFTR, trafficking, Cl-, Channels, VSAC, Chloride, KM11060

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