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NE 100 hydrochloride

Cat No. 3133

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Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanam ine hydrochloride

Biological Activity

Potent and selective σ₁ receptor antagonist (K_i = 0.86 nM) that displays > 55-fold selectivity over σ₂ receptors and > 6000-fold selectivity over D₁, D₂, 5-HT_1A, 5-HT₂ and PCP receptors. Exhibits reversible binding (K_d = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.

Technical Data

M.Wt:

391.97

Formula:

C₂₃H₃₃NO₂.HCl

Solubility:

Soluble to 25 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[149409-57-4]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Okuyama et al (1993) NE-100, a novel sigma receptor ligand: in vivo tests. Pharmacol.Letts. 53 PL285. Chaki et al (1994) NE-100, a novel potent σ ligand, preferentially binds to σ₁ binding sites in guinea pig brain. Eur.J.Pharmacol. 251 R1. Tanaka et al (1995) Characteristics of binding of [³H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes. Naunyn Schmied.Arch.Pharmacol. 351 244.

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