R&D Systems Inc. Tocris Bioscience Boston Biochem

P1075

Cat. No. 1355

P1075 C12H17N5 [60559-98-0]

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Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine

Biological Activity

Potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).

Technical Data

M.Wt:
231.3
Formula:
C12H17N5
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
60559-98-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255. PMID: 8996204.

Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370. PMID: 10570067.

Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439. PMID: 11121575.

Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287. PMID: 10988346.

If you know of a relevant citation for this product please let us know.

Keywords: P1075, supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6

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