R&D Systems Inc. Tocris Bioscience Boston Biochem

P1075

Cat. No. 1355

P1075 C12H17N5 [60559-98-0]

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Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine

Biological Activity

Potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).

Technical Data

M.Wt:
231.3
Formula:
C12H17N5
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
60559-98-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255. PMID: 8996204.

Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370. PMID: 10570067.

Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439. PMID: 11121575.

Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287. PMID: 10988346.

If you know of a relevant citation for this product please let us know.

Keywords: P1075, supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6

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