Cat. No. 1355

P1075 C12H17N5 [60559-98-0]

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Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine

Biological Activity

Potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).

Technical Data

Soluble to 50 mM in ethanol and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255. PMID: 8996204.

Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370. PMID: 10570067.

Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439. PMID: 11121575.

Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287. PMID: 10988346.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: P1075, supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6, Inward Rectifier Potassium (Kir) Channel Activators

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