Cat. No. 0448

Calpeptin C20H30N2O4 [117591-20-5]

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Chemical Name: N-Benzyloxycarbonyl-L-leucylnorleucinal

Biological Activity

Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Tsujinaka et al (1988) Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem.Biophys.Res.Commun. 153 1201. PMID: 2839170.

Sasaki et al (1990) Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195. PMID: 2079636.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150. PMID: 1877091.

Schoenwaelder and Burridge (1999) Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. J.Biol.Chem. 274 14359. PMID: 10318859.

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Keywords: Calpeptin, supplier, Calpain, cathepsin, L, inhibitors, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Calcium-Sensitive Protease Modulator Inhibitors

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