R&D Systems Inc. Tocris Bioscience Boston Biochem

Calpeptin

Cat. No. 0448

Calpeptin C20H30N2O4 [117591-20-5]

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Chemical Name: N-Benzyloxycarbonyl-L-leucylnorleucinal

Biological Activity

Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Technical Data

M.Wt:
362.47
Formula:
C20H30N2O4
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
117591-20-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

References

Tsujinaka et al (1988) Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem.Biophys.Res.Commun. 153 1201. PMID: 2839170.

Sasaki et al (1990) Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195. PMID: 2079636.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150. PMID: 1877091.

Schoenwaelder and Burridge (1999) Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. J.Biol.Chem. 274 14359. PMID: 10318859.

If you know of a relevant citation for this product please let us know.

Keywords: Calpeptin, supplier, Calpain, cathepsin, L, inhibitors, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling

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