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BMS CCR2 22

Cat No. 3129

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Chemical Name: 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(met hylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-( trifluoromethyl)benzamide

Biological Activity

High affinity CCR2 chemokine receptor antagonist (IC₅₀ = 5.1 nM). Displays potent functional antagonism, IC₅₀ values are 1 and 18 nM for antagonism of calcium flux and chemotaxis respectively. Selective over CCR3.

Technical Data

M.Wt:

593.66

Formula:

C₂₈H₃₄F₃N₅O₄S

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

[445479-97-0]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Cherney et al (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 51 721.

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Chemokine Receptors

Keywords: BMS CCR2 22, High, affinity, potent, CCR2, antagonists, Chemokine, Receptors, BMSCCR222

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