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Miglustat hydrochloride

Cat No. 3117

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Alternative Names: N-Butyldeoxynojirimycin hydrochloride, NB-DNJ

Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidin etriol hydrochloride

Biological Activity

Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Technical Data

M.Wt:

255.74

Formula:

C₁₀H₂₁NO₄

Solubility:

Soluble to 75 mM in water and to 75 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

[210110-90-0]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362. Dwek et al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 1 65. Noel et al (2008) Parallel improvements of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cytsic fibrosis epithelial cells. J.Pharamcol.Exp.Ther. 325 1016.

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Carbohydrate Metabolism Glycosylases

Other Transferases Transferases

Keywords: Miglustat hydrochloride, α-glucosidase, alpha-glucosidase, I, II, inhibits, inhibitors, ceramide-specific, glycosyltransferases, Glycosylases, Carbohydrate, Metabolism