Chromanol 293B

Cat. No. 1412

Chromanol 293B C15H20N2O4S [163163-23-3]

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Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

Biological Activity

Blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM). (-)-[3R,4S]-Chromanol 293B (Cat. No. 1475) also available.

Technical Data

M.Wt:
324.39
Formula:
C15H20N2O4S
Solubility:
Soluble to 20 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
163163-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007. PMID: 10696102.

Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590. PMID: 11414653.

Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472. PMID: 11332571.

If you know of a relevant citation for this product please let us know.

Keywords: Chromanol 293B, supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B

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