Cat. No. 1412
Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydr
Biological ActivityBlocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM). (-)-[3R,4S]-Chromanol 293B (Cat. No. 1475) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007. PMID: 10696102.
Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590. PMID: 11414653.
Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472. PMID: 11332571.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Chromanol 293B, supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B
Find multiple products by catalog number
New Products in this Area
Potent TREK-1 channel inhibitorLei-Dab 7
Potent, selective KCa2.2 blockerNS 8593 hydrochloride
Selective KCa2 (SK) channel negative modulator; inhibits SK currentsPK-THPP
Potent TASK-3 channel blockerML 297
Selective Kir3.1/3.2 (GIRK1/2) channel activator
September 5 - 8, 2015