Cat. No. 1412
Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydr
Biological ActivityBlocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM). (-)-[3R,4S]-Chromanol 293B (Cat. No. 1475) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007. PMID: 10696102.
Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590. PMID: 11414653.
Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472. PMID: 11332571.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Chromanol 293B, supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B
Find multiple products by catalog number
New Products in this Area
Potent KCa3.1 blockerBDS I
Potent and reversible Kv3.4 potassium channel blocker; neuroprotectiveAgitoxin 2
Potent Shaker K+ channel blockerMaxiPost
Potassium channel modulator; exerts subtype-specific effectsML 277
Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.