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Chromanol 293B

Cat. No. 1412

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Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

Biological Activity

Blocker of the slow delayed rectifier K⁺ current (I_Ks) (IC₅₀ = 1-10 μM). Also blocks the CFTR chloride current (I_CFTR) (IC₅₀ = 19 μM). (-)-[3R,4S]-Chromanol 293B (Cat. No. 1475) also available.

Technical Data

M.Wt:

324.39

Formula:

C₁₅H₂₀N₂O₄S

Solubility:

Soluble to 20 mM in ethanol and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

163163-23-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Enantiomer Available

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K⁺ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007. PMID: 10696102.

Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K⁺ current (I_KS), inhibits the CFTR Cl^- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590. PMID: 11414653.

Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472. PMID: 11332571.

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