GYKI 47261 dihydrochlorideCat No. 3099 |
Price and Availability |
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Chemical Name: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazep in-6-benzeneamine dihydrochloride |
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Biological Activity
Non-competitive AMPA receptor antagonist (IC50 = 2.5 μM). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Abraham et al (2000) New non competitive AMPA antagonists. Bioorg.Med.Chem. 8 2127. Solyom (2001) Research on new AMPA antagonists of 2,3-benzodiazepine type. Pharmazie 25 Suppl.1 S62. Bibbiani et al (2005) Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp.Neurol. 196 422.If you know of a useful citation for this product please let us know.
Keywords: GYKI 47261 dihydrochloride, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, GYKI47261, dihydrochloride
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