R&D Systems Inc. Tocris Bioscience Boston Biochem

Carbenoxolone disodium

Cat. No. 3096

Carbenoxolone disodium C34H48Na2O7 [7421-40-1]

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Chemical Name: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium

Biological Activity

Glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

Technical Data

M.Wt:
614.72
Formula:
C34H48Na2O7
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
7421-40-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Jellinck et al (1993) Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 46 209. PMID: 8664169.

Sagar and Larson (2006) Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 98 1543. PMID: 16552723.

If you know of a relevant citation for this product please let us know.

Keywords: Carbenoxolone disodium, supplier, Gap, junction, blockers, inhibitors, 11, β-hydroxysteroid, beta-hydroxysteroid, dehydrogenase, gap, Connexins, Channels, Dehydrogenases

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