Cat. No. 3090
Chemical Name: 3',4',5',6'-Tetrahydroxyspiro[isobenzof
Biological ActivityInhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lehmann et al (2008) Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol.Pharmacol. 73 410. PMID: 18006643.
Ukhanov et al (2011) Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J.Neurosci. 31 273. PMID: 21209212.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: Gallein, supplier, inhibitors, betagamma, signaling, G, Proteins, Heterotrimeric, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitors
Find multiple products by catalog number
New Products in this Area
Potent and selective GRK2/3 inhibitorPMX 53c
Negative control for PMX 53 (Cat. No. 5473)W 54011
High affinity C5a receptor antagonist
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AAI 2016.