Cat. No. 3090
Chemical Name: 3',4',5',6'-Tetrahydroxyspiro[isobenzof
Biological ActivityInhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
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For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Lehmann et al (2008) Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol.Pharmacol. 73 410. PMID: 18006643.
Ukhanov et al (2011) Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J.Neurosci. 31 273. PMID: 21209212.
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Keywords: Gallein, supplier, inhibitors, betagamma, signaling, G, Proteins, Heterotrimeric