R&D Systems Inc. Tocris Bioscience Boston Biochem

Gallein

Cat. No. 3090

Gallein C20H12O7 [2103-64-2]

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Chemical Name: 3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one

Biological Activity

Inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

Technical Data

M.Wt:
364.31
Formula:
C20H12O7
Solubility:
Soluble to 75 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
2103-64-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Lehmann et al (2008) Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol.Pharmacol. 73 410. PMID: 18006643.

Ukhanov et al (2011) Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J.Neurosci. 31 273. PMID: 21209212.

If you know of a relevant citation for this product please let us know.

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Keywords: Gallein, supplier, inhibitors, betagamma, signaling, G, Proteins, Heterotrimeric

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