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CJ 033466

Cat No. 3089

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Chemical Name: 5-Amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)-4-pipe ridinyl]methyl]-imidazo[1,2-a]pyridine-8-carboxamide

Biological Activity

Potent and selective 5-HT₄ partial agonist (EC₅₀= 0.927 nM). Displays > 1000-fold selectivity for 5-HT₄ over other 5-HT and D₂ receptors. Exhibits gastroprokinetic effects in vivo following oral administration. Weakly blocks hERG (IC₅₀ = 2.6 μM).

Technical Data

M.Wt:

377.91

Formula:

C₁₉H₂₈ClN₅O

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

[519148-48-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Toga et al (2007) The 5-HT₄ agonists cisapride, mosapride, and CJ-033466, a novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J.Pharmacol.Sci. 105 207. Mikami et al (2008) 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-a]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine₄ receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs. J.Pharmacol.Exp.Ther. 325 190.

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Keywords: CJ 033466, Selective, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, CJ033466

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