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NocodazoleCat. No. 1228 |
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Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester |
Biological Activity
Microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.Certificate of Analysis / Safety Data Sheet
References
Vasquez et al (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Mol.Biol.Cell 8 973. PMID: 9201709.
Mikhailov and Gundersen` (1998) Relationship between microtubule dynamics and lamellipodium formation revealed by direct imaging of microtubules in cells treated with nocodazole or taxol. Cell.Motil.Cytoskeleton 41 325. PMID: 9858157.
Webb et al (2004) Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int.J.Biochem.Cell Biol. 36 2541. PMID: 15325591.
Mizushima et al (2010) Methods in mammalian autophagy research. Cell 140 313. PMID: 20144757.
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Keywords: Nocodazole, supplier, Microtubule, inhibitors, Tau, Tubulin, Microtubules, Mitosis
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