Cat. No. 1228
Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimida
Biological ActivityMicrotubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Vasquez et al (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Mol.Biol.Cell 8 973. PMID: 9201709.
Mikhailov and Gundersen` (1998) Relationship between microtubule dynamics and lamellipodium formation revealed by direct imaging of microtubules in cells treated with nocodazole or taxol. Cell.Motil.Cytoskeleton 41 325. PMID: 9858157.
Webb et al (2004) Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int.J.Biochem.Cell Biol. 36 2541. PMID: 15325591.
Mizushima et al (2010) Methods in mammalian autophagy research. Cell 140 313. PMID: 20144757.
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Keywords: Nocodazole, supplier, Microtubule, inhibitors, Tau, Tubulin, Microtubules, Mitosis
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March 17, 2015