R&D Systems Inc. Tocris Bioscience Boston Biochem

Nocodazole

Cat. No. 1228

Nocodazole C14H11N3O3S [31430-18-9]

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Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester

Biological Activity

Microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.

Technical Data

M.Wt:
301.32
Formula:
C14H11N3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>95 %
Storage:
Store at RT
CAS No:
31430-18-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Vasquez et al (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Mol.Biol.Cell 8 973. PMID: 9201709.

Mikhailov and Gundersen` (1998) Relationship between microtubule dynamics and lamellipodium formation revealed by direct imaging of microtubules in cells treated with nocodazole or taxol. Cell.Motil.Cytoskeleton 41 325. PMID: 9858157.

Webb et al (2004) Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int.J.Biochem.Cell Biol. 36 2541. PMID: 15325591.

Mizushima et al (2010) Methods in mammalian autophagy research. Cell 140 313. PMID: 20144757.

If you know of a relevant citation for this product please let us know.

Keywords: Nocodazole, supplier, Microtubule, inhibitors, Tau, Tubulin, Microtubules, Mitosis

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