Nocodazole

Cat. No. 1228

Nocodazole C14H11N3O3S [31430-18-9]

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Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester

Biological Activity

Microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.

Technical Data

M.Wt:
301.32
Formula:
C14H11N3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>95 %
Storage:
Store at RT
CAS No:
31430-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Vasquez et al (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Mol.Biol.Cell 8 973. PMID: 9201709.

Mikhailov and Gundersen` (1998) Relationship between microtubule dynamics and lamellipodium formation revealed by direct imaging of microtubules in cells treated with nocodazole or taxol. Cell.Motil.Cytoskeleton 41 325. PMID: 9858157.

Webb et al (2004) Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int.J.Biochem.Cell Biol. 36 2541. PMID: 15325591.

Mizushima et al (2010) Methods in mammalian autophagy research. Cell 140 313. PMID: 20144757.

If you know of a relevant citation for this product please let us know.

Keywords: Nocodazole, supplier, Microtubule, inhibitors, Tau, Tubulin, Microtubules, Mitosis

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