R&D Systems Inc. Tocris Bioscience Boston Biochem

Apigenin

Cat. No. 1227

Apigenin C15H10O5 [520-36-5]

Price and Availability

For Apigenin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Biological Activity

Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Technical Data

M.Wt:
270.2
Formula:
C15H10O5
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Desiccate at +4°C
CAS No:
520-36-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 204 578. PMID: 7980517.

Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 212 767. PMID: 7626110.

Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39. PMID: 9589348.

Choi et al (2009) Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 44 260. PMID: 19430615.

Jin et al (2009) Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 616 200. PMID: 19549516.

If you know of a relevant citation for this product please let us know.

Keywords: Apigenin, supplier, Protein, kinase, inhibitors, Kinases, Broad, Spectrum

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

CHR 6494 trifluoroacetate

Potent and selective haspin kinase inhibitor

UNC 3230

Potent and selective PIP5K1C inhibitor; antinociceptive

BMS 509744

Potent and selective ITK kinase inhibitor

WZ 4003

Potent and selective NUAK1/2 inhibitor

TC-S 7010

Potent and selective Aurora kinase A inhibitor

Bryostatin 2

Protein kinase C activator

ZLN 024 hydrochloride

Allosteric AMPK activator

Temsirolimus

mTOR inhibitor; antitumor

KN 93 phosphate

CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

Bryostatin 3

Potent protein kinase C activator

GKA 50

Glucokinase activator

MRT 67307 dihydrochloride

Salt inducible kinase (SIK) inhibitor

LDN 209929 dihydrochloride

Potent and selective haspin kinase inhibitor

RKI 1447 dihydrochloride

Potent and selective ROCK inhibitor; antitumor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.