Cat. No. 1136
Chemical Name: 9,10-Deepithio-9,10-didehydroacanth
Biological ActivityPotent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promotor. Shown to activate atypical protein kinase C in adipocytes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 6958.
Haystead et al (1989) Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337 78. PMID: 2562908.
Cohen et al (1990) Okadaic acid: a new probe for the study of cellular regulation. TiBS 15 98. PMID: 2158158.
Nuydens et al (1998) Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 70 1124. PMID: 9489733.
Standaert et al (1999) Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes. J.Biol.Chem. 274 14074. PMID: 10318822.
McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151. PMID: 11881984.
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Keywords: Okadaic acid, supplier, Protein, phosphatase, 1, 2A, inhibitor, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A