Cat. No. 1136
Chemical Name: 9,10-Deepithio-9,10-didehydroacanth
Biological ActivityPotent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promotor. Shown to activate atypical protein kinase C in adipocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 6958.
Haystead et al (1989) Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337 78. PMID: 2562908.
Cohen et al (1990) Okadaic acid: a new probe for the study of cellular regulation. TiBS 15 98. PMID: 2158158.
Nuydens et al (1998) Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 70 1124. PMID: 9489733.
Standaert et al (1999) Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes. J.Biol.Chem. 274 14074. PMID: 10318822.
McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151. PMID: 11881984.
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Keywords: Okadaic acid, supplier, Protein, phosphatase, 1, 2A, inhibitor, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A
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