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Spermine NONOate

Cat. No. 1135

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Chemical Name: N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl-1,3-propanediamine

Biological Activity

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC₅₀ = 6.2 μM for relaxation of rabbit aorta, and t_½ =39 min at 37°C, pH 7.4, aqueous solution).

Licensing Information

Sold with the permission of the NIH, US Patent 5,155,137

Technical Data

M.Wt:

262.35

Formula:

C₁₀H₂₆N₆O₂

Solubility:

Soluble to 100 mM in water

Storage:

Desiccate at -20°C

CAS No:

136587-13-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Maragos et al (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J.Med.Chem. 34 3242. PMID: 1956043.

Ramamurthi and Lewis (1997) Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem.Res.Toxicol. 10 408. PMID: 9114977.

Homer and Wanstall (1998) In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur.J.Pharmacol. 356 49. PMID: 9761423.

Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779. PMID: 10401570.

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