BRL 37344, sodium salt

Cat. No. 0948

BRL 37344, sodium salt C19H21NO4ClNa [127299-93-8]

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Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt

Biological Activity

Potent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively). Also available as part of the β-Adrenoceptor Agonist Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

Soluble to 100 mM in water
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Arch et al (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309 163. PMID: 6325935.

Ayo Oriowo et al (1996) The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 277 22. PMID: 8613923.

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373. PMID: 8979772.

Board et al (2000) BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 406 33. PMID: 11011029.

If you know of a relevant citation for this product please let us know.

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Keywords: BRL 37344, sodium salt, supplier, β3-adrenoceptor, b3-adrenoceptor, agonists, β3-adrenergic, b3-adrenergic, Receptors, BRL37344, sodium, salt, GlaxoSmithKline, GSK, Adrenergic β3 Agonists

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