R&D Systems Inc. Tocris Bioscience Boston Biochem

BRL 37344, sodium salt

Cat. No. 0948

BRL 37344, sodium salt C19H21NO4ClNa [127299-93-8]

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Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt

Biological Activity

Potent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively). Also available as part of the β-Adrenoceptor Agonist Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
385.82
Formula:
C19H21NO4ClNa
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
127299-93-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Arch et al (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309 163. PMID: 6325935.

Ayo Oriowo et al (1996) The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 277 22. PMID: 8613923.

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373. PMID: 8979772.

Board et al (2000) BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 406 33. PMID: 11011029.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: BRL 37344, sodium salt, supplier, β3-adrenoceptor, b3-adrenoceptor, agonists, β3-adrenergic, b3-adrenergic, Receptors, BRL37344, sodium, salt, GlaxoSmithKline, GSK

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