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BRL 37344, sodium salt

Cat. No. 0948

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Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt

Biological Activity

Potent and selective β₃ adrenoceptor agonist (K_i values are 287, 1750 and 1120 nM for β₃, β₁ and β₂ receptors respectively). Also available as part of the β-Adrenoceptor Agonist Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:

385.82

Formula:

C₁₉H₂₁NO₄ClNa

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Store at RT

CAS No:

127299-93-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Arch et al (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309 163. PMID: 6325935.

Ayo Oriowo et al (1996) The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 277 22. PMID: 8613923.

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β₃-adrenoceptor. TiPS 17 373. PMID: 8979772.

Board et al (2000) BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 406 33. PMID: 11011029.

If you know of a relevant citation for this product please let us know.

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7-TM Receptor Signaling

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'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy