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Gabapentin

Cat. No. 0806

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Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid

Biological Activity

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca²⁺ channels. Prevents neuronal death and is antinociceptive and anxiolytic.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:

171.24

Formula:

C₉H₁₇NO₂

Solubility:

Soluble to 100 mM in water with gentle warming

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

60142-96-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456. PMID: 7886818.

Taylor et al (1998) A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 29 233. PMID: 9551785.

Fink et al (2000) Inhibition of Ca²⁺ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900. PMID: 10864898.

Timmerman et al (2000) A microdialysis study on the mechanism of action of gabapentin. Eur.J.Pharmacol. 398 53. PMID: 10856447.

If you know of a relevant citation for this product please let us know.

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