(±)-Bisoprolol hemifumarate

Cat. No. 0914

()-Bisoprolol hemifumarate C18H31NO4.C4H4O4 [104344-23-2]

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Chemical Name: (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate

Biological Activity

A selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.

Technical Data

M.Wt:
383.48
Formula:
C18H31NO4.½C4H4O4
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
104344-23-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kaumann and Lemoine (1985) Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. Naunyn Schmiedebergs Arch.Pharmacol. 331 27. PMID: 2866449.

Klockow et al (1986) Studies on the receptor profile of bisoprolol. Arzneimittelforschung 36 197. PMID: 2870719.

Heible et al (1995) α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415. PMID: 7658428.

If you know of a relevant citation for this product please let us know.

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Keywords: ()-Bisoprolol hemifumarate, supplier, α1-adrenoceptor, beta1-adrenoceptor, β1-Adrenergic, beta1-Adrenergic, b1-adrenoceptor, b1-adrenergic, antagonists, Receptors, Tocris Bioscience, Adrenergic β1 Receptors Antagonists

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