R&D Systems Inc. Tocris Bioscience Boston Biochem

(±)-Bisoprolol hemifumarate

Cat. No. 0914

()-Bisoprolol hemifumarate C18H31NO4.C4H4O4 [104344-23-2]

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Chemical Name: (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate

Biological Activity

A selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.

Technical Data

M.Wt:
383.48
Formula:
C18H31NO4.½C4H4O4
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
104344-23-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kaumann and Lemoine (1985) Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. Naunyn Schmiedebergs Arch.Pharmacol. 331 27. PMID: 2866449.

Klockow et al (1986) Studies on the receptor profile of bisoprolol. Arzneimittelforschung 36 197. PMID: 2870719.

Heible et al (1995) α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415. PMID: 7658428.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: ()-Bisoprolol hemifumarate, supplier, α1-adrenoceptor, beta1-adrenoceptor, β1-Adrenergic, beta1-Adrenergic, b1-adrenoceptor, b1-adrenergic, antagonists, Receptors

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