Home » Pharmacology » 7-TM Receptors » Opioid Receptors » κ Opioid Receptors » nor-Binaltorphimine dihydrochloride

nor-Binaltorphimine dihydrochloride

Cat. No. 0347

Price and Availability

For nor-Binaltorphimine dihydrochloride pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: nor-BNI, Norbinaltorphimine

Chemical Name: 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride

Biological Activity

A selective κ-opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data

M.Wt:

734.72

Formula:

C₄₀H₄₃N₃O₆.2HCl

Solubility:

Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

105618-26-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Portoghese et al (1994) Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17'-basic group in the interaction with a putative address subsite on the κ opioid receptor. J.Med.Chem. 37 1495. PMID: 8182708.

Blake et al (1997) Differential agonist regulation of the human κ-opioid receptor. J.Neurochem. 68 1846. PMID: 9109509.

Feng et al (1997) Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol- but not morphine-dependent rats. J.Pharmacol.Exp.Ther. 283 932. PMID: 9353416.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

κ Opioid Receptors

Opioid Receptors

Keywords: nor-Binaltorphimine dihydrochloride, supplier, selective, antagonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2

Quick Order

Find multiple products by catalog number

Pain Research Guide

Reserve your free copy

Highlights over 280 products for Pain research. Reserve copy

Appetite Modulation

Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

New Product Guide

Highlights over 130 new products added in 2012. Request a copy or view PDF today.

Tocris Events

Win a Kindle

11th Annual Meeting of the International Society for Stem Cell Research

June 12 - 15, 2013

Boston, MA

Booth Number: 213