Cat. No. 0347
Alternative Names: nor-BNI, Norbinaltorphimine
Chemical Name: 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride
Biological ActivityA selective κ-opioid receptor antagonist.
Licensing InformationSold with the permission of the University of Minnesota
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Portoghese et al (1994) Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17'-basic group in the interaction with a putative address subsite on the κ opioid receptor. J.Med.Chem. 37 1495. PMID: 8182708.
Blake et al (1997) Differential agonist regulation of the human κ-opioid receptor. J.Neurochem. 68 1846. PMID: 9109509.
Feng et al (1997) Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol- but not morphine-dependent rats. J.Pharmacol.Exp.Ther. 283 932. PMID: 9353416.
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Keywords: nor-Binaltorphimine dihydrochloride, supplier, selective, antagonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2
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