Cat. No. 0130

(+)-Bicuculline C20H17NO6 [485-49-4]

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Chemical Name: [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Biological Activity

Classical GABAA antagonist. Methoiodide salt (Cat. No. 2503), Methobromide salt (Cat. No. 0109) and Methochloride salt (Cat. No. 0131) also available.

Technical Data

Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Merck Index 12 1250.

Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222. PMID: 4393081.

Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283. PMID: 1247886.

Piredda et al (1985) Intracerebral site of convulsant action of bicuculline. Life Sci. 36 1295. PMID: 3982215.

Sieghart et al (1989) Multiplicity of GABAA-benzodiazepine receptors. TiPS 10 407. PMID: 2559519.

If you know of a relevant citation for this product please let us know.

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Keywords: (+)-Bicuculline, supplier, Potent, GABAA, antagonists, Receptors, GABAA Receptor Antagonists

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