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(+)-Bicuculline

Cat. No. 0130

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Chemical Name: [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Biological Activity

Classical GABA_A antagonist. Methoiodide salt (Cat. No. 2503), Methobromide salt (Cat. No. 0109) and Methochloride salt (Cat. No. 0131) also available.

Technical Data

M.Wt:

367.36

Formula:

C₂₀H₁₇NO₆

Solubility:

Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

485-49-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 1250.

Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222. PMID: 4393081.

Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283. PMID: 1247886.

Piredda et al (1985) Intracerebral site of convulsant action of bicuculline. Life Sci. 36 1295. PMID: 3982215.

Sieghart et al (1989) Multiplicity of GABA_A-benzodiazepine receptors. TiPS 10 407. PMID: 2559519.

If you know of a relevant citation for this product please let us know.

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