Home » Pharmacology » Ion Channels » Ligand-gated Ion Channels » GABA_A and GABA_C Receptors » GABA_A Receptors » SR 95531 hydrobromide

SR 95531 hydrobromide

Cat. No. 1262

Price and Availability

For SR 95531 hydrobromide pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Gabazine

Chemical Name: 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide

Biological Activity

Selective, competitive GABA_A receptor antagonist. Displaces [³H]-GABA from rat brain membranes with a K_i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl^- currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Technical Data

M.Wt:

368.23

Formula:

C₁₅H₁₇N₃O₃.HBr

Solubility:

Soluble to 25 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

104104-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Heaulme et al (1986) Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABA_A receptor site. Brain Res. 384 224. PMID: 3022866.

Uchida et al (1996) The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons. Eur.J.Pharmacol. 307 89. PMID: 8831109.

Beato et al (2007) The kinetics of inhibition of rat recombinant heterotrimeric α1β glycine receptors by the low affinity antagonist SR-95531. J.Physiol. 580 171. PMID: 17218350.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

GABA_A and GABA_C Receptors

GABA_A Receptors

Keywords: SR 95531 hydrobromide, supplier, Selective, competitive, GABAA, receptor, antagonists, Receptors, SR95531, hydrobromide

Quick Order

Find multiple products by catalog number

Pain Research Guide

Reserve your free copy

Highlights over 280 products for Pain research. Reserve copy

GABA Review

Written by Ian Martin, Norman Bowery & Susan Dunn. Request a copy or view PDF today.

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

New Product Guide

Highlights over 130 new products added in 2012. Request a copy or view PDF today.

20% Discount*

Potent, selective LRRK2 inhibitor

Potent LRRK2 inhibitor now available from Tocris Bioscience

Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.

* Terms & conditions