R&D Systems Inc. Tocris Bioscience Boston Biochem

SR 95531 hydrobromide

Cat. No. 1262

SR 95531 hydrobromide C15H17N3O3.HBr [104104-50-9]

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Alternative Name: Gabazine

Chemical Name: 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide

Biological Activity

Selective, competitive GABAA receptor antagonist. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl- currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Technical Data

M.Wt:
368.23
Formula:
C15H17N3O3.HBr
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
104104-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Heaulme et al (1986) Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site. Brain Res. 384 224. PMID: 3022866.

Uchida et al (1996) The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons. Eur.J.Pharmacol. 307 89. PMID: 8831109.

Beato et al (2007) The kinetics of inhibition of rat recombinant heterotrimeric α1β glycine receptors by the low affinity antagonist SR-95531. J.Physiol. 580 171. PMID: 17218350.

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Keywords: SR 95531 hydrobromide, supplier, Selective, competitive, GABAA, receptor, antagonists, Receptors, SR95531, hydrobromide

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