Cat. No. 1085
Biological ActivityPeptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.
(Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Tsien et al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431. PMID: 2469160.
Sato et al (1993) Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem.Biophys.Res.Comm. 194 1292. PMID: 8394704.
Wright and Angu (1997) Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 30 392. PMID: 9300325.
Connelly et al (2011) Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Eur.J.Pharmacol. 667 160. PMID: 21575629.
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Keywords: w-Conotoxin GVIA, supplier, Ca2+, channel, blockers, N-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, GVIA, neurotoxins
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March 28 - April 1, 2015