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ω-Conotoxin GVIA

Cat No. 1085

w-Conotoxin GVIA Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bridges: 1 - 16, 8 - 19, 15 - 26)

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Biological Activity

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels.

Technical Data

M.Wt:

3037

Formula:

C₁₂₀H₁₈₈N₃₈O₄₃S₆

Sequence:

CKSXGSSCSXTSYNCCRSCNXYTKRCY

(Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide)

Storage:

Desiccate at -20°C

CAS No:

[106375-28-4]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Tsien et al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431. Casali et al (1997) Different effects of reducing agents on w-conotoxin GVIA inhibition of [³H]-acetylcholine release from rat cortical slices and guinea-pig myenteric plexus. Br.J.Pharmacol. 120 88. Wright and Angus (1997) Prolonged cardiovascular effects of the N-type Ca²⁺ channel antagonist w-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 30 392.

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Keywords: w-Conotoxin GVIA, Ca2+, channel, blockers, N-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, GVIA

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