Cat. No. 1316
Biological ActivityA high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Derivative tertiapin LQ (Cat. No. 4339) also available.
Licensing InformationSold under license granted by the University of Pennsylvania
(Modifications: Disulfide bridge between 3 - 14, 5 - 18, Lys-21 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jin et al (1999) Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q. Biochemistry 38 14294. PMID: 10572004.
Jin and Lu (1999) Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels. Biochemistry 38 14286. PMID: 10572003.
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Keywords: Tertiapin-Q, supplier, Potent, selective, blockers, inward-rectifier, K+, channels, Potassium, KIR, Channels, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blockers