Cat. No. 1316
Biological ActivityA high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Derivative tertiapin LQ (Cat. No. 4339) also available.
Licensing InformationSold under license granted by the University of Pennsylvania
(Modifications: Disulfide bridge between 3 - 14, 5 - 18, Lys-21 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Jin et al (1999) Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q. Biochemistry 38 14294. PMID: 10572004.
Jin and Lu (1999) Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels. Biochemistry 38 14286. PMID: 10572003.
If you know of a relevant citation for this product please let us know.
Keywords: Tertiapin-Q, supplier, Potent, selective, blockers, inward-rectifier, K+, channels, Potassium, KIR, Channels
Find multiple products by catalog number
New Products in this Area
Potent KCa3.1 blockerBDS I
Potent and reversible Kv3.4 potassium channel blocker; neuroprotectiveAgitoxin 2
Potent Shaker K+ channel blockerMaxiPost
Potassium channel modulator; exerts subtype-specific effects
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.