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AG 555

Cat. No. 0618

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Alternative Name: Tyrphostin AG 555

Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide

Biological Activity

Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G₁ growth arrest selectively in transformed cells (IC₅₀ values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).

Technical Data

M.Wt:

322.36

Formula:

C₁₉H₁₈N₂O₃

Solubility:

Soluble to 30 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

133550-34-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782. PMID: 7892601.

Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442. PMID: 10454524.

If you know of a relevant citation for this product please let us know.

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