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Tyrphostin B44, (-) enantiomer

Cat. No. 0578

(-)-Tyrphostin B44 C18H16N2O3 [133550-32-0]

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Chemical Name: (R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC₅₀ = 0.4 μM), more active than the (+) enantiomer (Cat. No. 0579). Selective over ErbB2.

Technical Data

M.Wt:

308.34

Formula:

C₁₈H₁₆N₂O₃

Solubility:

Soluble to 30 mM in DMSO

Storage:

Desiccate at +4°C

CAS No:

133550-32-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

(+)-enantiomer Available

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

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