Tyrphostin B44, (-) enantiomer

Cat. No. 0578

Tyrphostin B44, (-) enantiomer C18H16N2O3 [133550-32-0]

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Chemical Name: (R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM), more active than the (+) enantiomer (Cat. No. 0579). Selective over ErbB2.

Technical Data

Soluble to 30 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

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