R&D Systems Inc. Tocris Bioscience Boston Biochem

AG 18

Cat. No. 0493

AG 18 C10H6N2O2 [118409-57-7]

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Alternative Names: RG-50810, Tyrphostin A23

Chemical Name: [(3,4-Dihydroxyphenyl)methylene]-propenedinitrile

Biological Activity

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Technical Data

M.Wt:
186.17
Formula:
C10H6N2O2
Storage:
Desiccate at +4°C
CAS No:
118409-57-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Gazit et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933. PMID: 3263702.

Gazit et al (1989) Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J.Biol.Chem. 264 14503. PMID: 2788167.

Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344. PMID: 2552117.

Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782. PMID: 7892601.

Soltoff (2004) Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J.Biol.Chem. 279 10910. PMID: 14688271.

If you know of a relevant citation for this product please let us know.

Keywords: AG 18, supplier, EGFR, PDGFR, kinase, inhibitors, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, Platelet, Derived, AG18, RG50810

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