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UCL 1684

Cat. No. 1310

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Chemical Name: 6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide

Biological Activity

Highly potent, non-peptidic blocker of the apamin-sensitive Ca²⁺-activated K⁺ channel (K_Ca2.1) (IC₅₀ = 3 nM in rat sympathetic neurons). Blocks hK_Ca2.1 and rK_Ca2.2 channels expressed in HEK 293 cells with IC₅₀ values of 762 and 364 pM respectively.

Licensing Information

Sold with the permission of University College, London

Technical Data

M.Wt:

654.44

Formula:

C₃₄H₃₀Br₂N₄

Solubility:

Soluble to 10 mM in DMSO

Purity:

>97 %

Storage:

Desiccate at RT

CAS No:

199934-16-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Campos Rosa et al (2000) Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca²⁺-activated K⁺ channel. J.Med.Chem. 43 420. PMID: 10669569.

Malik-Hall et al (2000) Compounds that block intermediate-conductance (IK_Ca) and small-conductance (SK_Ca) calcium-activated potassium channels. Br.J.Pharmacol. 129 1431. PMID: 10742299.

Strobaek et al (2000) Pharmacological characterization of small-conductance Ca²⁺-activated K⁺ channels stably expressed in HEK 293 cells. Br.J.Pharmacol. 129 991. PMID: 10696100.

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