UCL 1684

Cat. No. 1310

UCL 1684 C34H30Br2N4 [199934-16-2]

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Chemical Name: 6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide

Biological Activity

Highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). Blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively.

Licensing Information

Sold with the permission of University College, London

Technical Data

M.Wt:
654.44
Formula:
C34H30Br2N4
Solubility:
Soluble to 10 mM in DMSO
Purity:
>97 %
Storage:
Desiccate at RT
CAS No:
199934-16-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Campos Rosa et al (2000) Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel. J.Med.Chem. 43 420. PMID: 10669569.

Malik-Hall et al (2000) Compounds that block intermediate-conductance (IKCa) and small-conductance (SKCa) calcium-activated potassium channels. Br.J.Pharmacol. 129 1431. PMID: 10742299.

Strobaek et al (2000) Pharmacological characterization of small-conductance Ca2+-activated K+ channels stably expressed in HEK 293 cells. Br.J.Pharmacol. 129 991. PMID: 10696100.

If you know of a relevant citation for this product please let us know.

Keywords: UCL 1684, supplier, potent, blockers, SKCa, Potassium, Channels, K+, ca2+-activated, ca2+-dependent, SK1, SK2, UCL1684

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