R&D Systems Inc. Tocris Bioscience Boston Biochem

Macbecin I

Cat. No. 3061

Macbecin I C30H42N2O8 [73341-72-7]

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Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

Biological Activity

Ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).

Technical Data

M.Wt:
558.67
Formula:
C30H42N2O8
Solubility:
Soluble in DMSO
Storage:
Desiccate at -20°C
CAS No:
73341-72-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Ono et al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938. PMID: 6186564.

Uehara et al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325. PMID: 14529384.

Martin et al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853. PMID: 18357975.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Macbecin I, supplier, Hsp90, inhibitors, Heat, Shock, Protein, 90, MacbecinI, antibiotics

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