R&D Systems Inc. Tocris Bioscience Boston Biochem

RO-3

Cat. No. 3052

RO-3 C16H22N4O2 [1026582-88-6]

Price and Availability

For RO-3 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-[[4,5-Dimethoxy-2-(methylethyl)ph­enyl]methyl]-2,4-pyrimidinediamine

Biological Activity

Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

Technical Data

M.Wt:
302.37
Formula:
C16H22N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
1026582-88-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132. PMID: 16465177.

Gever et al (2006) Pharmacology of P2X channels. Eur.J.Physiol. 452 513.

Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409. PMID: 18042830.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: RO-3, supplier, Selective, P2X2, P2X2/3, antagonists, Receptors, Purinergic, purinoceptors

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

P2 Receptors Review

Purinergic Receptor Review

Written by Kenneth Jacobson, an expert in the field. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights over 130 new products added in 2012. Request a copy or view PDF today.

divider line

New Products in this Area

PU 02

Negative allosteric modulator of 5-HT3

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.