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RO-3Cat. No. 3052 |
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Chemical Name: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine |
Biological Activity
Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.Certificate of Analysis / Safety Data Sheet
References
Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132. PMID: 16465177.
Gever et al (2006) Pharmacology of P2X channels. Eur.J.Physiol. 452 513.
Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409. PMID: 18042830.
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Keywords: RO-3, supplier, Selective, P2X2, P2X2/3, antagonists, Receptors, Purinergic, purinoceptors
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