RO-3

Cat No. 3052

RO-3 C16H22N4O2

Price and Availability

For RO-3 pricing & availability please select your country from the drop down menu:
Submit

Chemical Name: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyr imidinediamine

Biological Activity

Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

Technical Data

M.Wt:
302.37
Formula:
C16H22N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
For specific/earlier batch please select:  
Material Safety Data Sheet: View current batch
For specific/earlier batch please select:  

References

Gever et al (2006) Pharmacology of P2X channels. Eur.J.Physiol. 452 513. Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132. Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409.

If you know of a useful citation for this product please let us know.

View Related Products by Target

Keywords: RO-3, Selective, P2X2, P2X2/3, antagonists, Receptors, Purinergic, purinoceptors

Buy Now / Print Quote

Find multiple products by catalog number


divider line

Print Quote Facility

Order via your purchasing department

Print Quote Facility

It's now even easier to place orders via your purchasing department.

Simply add a product to your cart & click on the "Print Quote" button.

more
divider line

Modulators of Peripheral Sensitization

Written by M.R. Vasko and G.D. Nicol

Pain Poster

'Pharmacological Modulators of Peripheral Sensitization' summarizes the inhibitory and excitatory modulators of peripheral sensitization.

request
divider line

Purinergic Receptor Review

Purinergic Receptor Review

Written by Kenneth Jacobson, an expert in the field. Request a copy or view PDF today.

request
divider line

New Products in this Area

5-BDBD

Potent P2X4 receptor antagonist

Sign-up for new product e-alerts
divider line

2009-10 Catalog

2009-2010 Tocris Catalog

Our range of over 3,000 life science reagents represents a unique collection of novel and exclusive research tools. Request a copy or view PDF today.

request